Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics.
Trends Pharmacol Sci
; 40(10): 774-789, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-31515079
ABSTRACT
Aldehyde dehydrogenases (ALDHs) are highly expressed in the chemotherapy- and radiotherapy-resistant cell subpopulations of many different cancer types. Accordingly, the development of ALDH inhibitors may be the most direct approach to target these cell populations. However, inhibiting multiple ALDH family members can be toxic and isoform-specific inhibition is often ineffective. This review discusses the role of ALDH in cancer and therapy resistance, and then overviews the various available ALDH inhibitors with a focus on the clinical potential and limitations of these agents as cancer therapeutics. Finally, challenges and future research directions to effectively target ALDH in the management of cancer therapy resistance are discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aldehído Deshidrogenasa
/
Inhibidores Enzimáticos
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos