Organic small molecule for detection and photodegradation of mitochondrial DNA mutations.
J Mater Chem B
; 7(39): 5947-5955, 2019 10 09.
Article
en En
| MEDLINE
| ID: mdl-31517375
ABSTRACT
A detection and degradation platform was developed to optically quantify the 6-enolate, 8-keto-dG, an important tautomer of mitochondrial mutated DNA 8-oxo-dG. We first found that 6-enolate, 8-keto-dG offers particular fluorescence emission under the conditions between pH â¼ 7 and â¼11. Thus, a mitochondria-targeting photosensitizer NV-12P was prepared to offer simultaneously photoinduced electron transfer and fluorescence resonance energy transfer (FRET) with 6-enolate, 8-keto-dG. Furthermore, NV-12P can also generate a reactive oxygen species to degrade 6-enolate, 8-keto-dG under irradiation conditions. This is the first publication about optical characterization, concentration detection and photodegradation of 6-enolate, 8-keto-dG, either in biological or in vitro applications.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotólisis
/
ADN Mitocondrial
/
8-Hidroxi-2'-Desoxicoguanosina
/
Mutación
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Mater Chem B
Año:
2019
Tipo del documento:
Article
País de afiliación:
Taiwán