Treatment response after 6 and 26 weeks is related to baseline glutamate and GABA levels in antipsychotic-naïve patients with psychosis.

Bojesen, Kirsten B; Ebdrup, Bjørn H; Jessen, Kasper; Sigvard, Anne; Tangmose, Karen; Edden, Richard A E; Larsson, Henrik B W; Rostrup, Egill; Broberg, Brian V; Glenthøj, Birte Y

Bojesen, Kirsten B; Ebdrup, Bjørn H; Jessen, Kasper; Sigvard, Anne; Tangmose, Karen; Edden, Richard A E; Larsson, Henrik B W; Rostrup, Egill; Broberg, Brian V; Glenthøj, Birte Y.

Afiliación

Bojesen KB; Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Ebdrup BH; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen, Denmark.
Jessen K; Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Sigvard A; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen, Denmark.
Tangmose K; Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Edden RAE; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen, Denmark.
Larsson HBW; Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Rostrup E; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen, Denmark.
Broberg BV; Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Glenthøj BY; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen, Denmark.

Psychol Med ; 50(13): 2182-2193, 2020 10.

Article en En | MEDLINE | ID: mdl-31524118

Asunto(s)

Antipsicóticos/uso terapéutico; Ácido Glutámico/efectos de los fármacos; Trastornos Psicóticos/tratamiento farmacológico; Ácido gamma-Aminobutírico/efectos de los fármacos; Adolescente; Adulto; Estudios de Casos y Controles; Femenino; Ácido Glutámico/análisis; Ácido Glutámico/metabolismo; Giro del Cíngulo/efectos de los fármacos; Giro del Cíngulo/metabolismo; Humanos; Modelos Logísticos; Espectroscopía de Resonancia Magnética/métodos; Masculino; Escalas de Valoración Psiquiátrica; Tálamo/efectos de los fármacos; Tálamo/metabolismo; Factores de Tiempo; Adulto Joven; Ácido gamma-Aminobutírico/análisis; Ácido gamma-Aminobutírico/metabolismo

Palabras clave

Anterior cingulate cortex; GABA; antipsychotic-naïve; first-episode psychosis; glutamate; magnetic resonance spectroscopy; thalamus; treatment outcome

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Antipsicóticos / Ácido Glutámico / Ácido gamma-Aminobutírico Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Psychol Med Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido

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