Chromosomal microarray analysis in prenatal diagnosis: ethical considerations of the Belgian approach.
J Med Ethics
; 46(2): 104-109, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31527144
ABSTRACT
Detection of genetic aberrations in prenatal samples, obtained through amniocentesis or chorion villus biopsy, is increasingly performed using chromosomal microarray (CMA), a technique that can uncover both aneuploidies and copy number variants throughout the genome. Despite the obvious benefits of CMA, the decision on implementing the technology is complicated by ethical issues concerning variant interpretation and reporting. In Belgium, uniform guidelines were composed and a shared database for prenatal CMA findings was established. This Belgian approach sparks discussion:
it is evidence-based, prevents inconsistencies and avoids parental anxiety, but can be considered paternalistic. Here, we reflect on the cultural and moral bases of the Belgian reporting system of prenatally detected variants.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Padres
/
Diagnóstico Prenatal
/
Cromosomas
/
Trastornos de los Cromosomas
/
Revelación
/
Ética Médica
/
Variaciones en el Número de Copia de ADN
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Qualitative_research
Aspecto:
Ethics
Límite:
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Med Ethics
Año:
2020
Tipo del documento:
Article
País de afiliación:
Bélgica