Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced ß-cell dysfunction.

Taneera, Jalal; Mohammed, Israa; Mohammed, Abdul Khader; Hachim, Mahmood; Dhaiban, Sarah; Malek, Abdullah; Dunér, Pontus; Elemam, Noha M; Sulaiman, Nabil; Hamad, Mawieh; Salehi, Albert

Taneera, Jalal; Mohammed, Israa; Mohammed, Abdul Khader; Hachim, Mahmood; Dhaiban, Sarah; Malek, Abdullah; Dunér, Pontus; Elemam, Noha M; Sulaiman, Nabil; Hamad, Mawieh; Salehi, Albert.

Afiliación

Taneera J; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates. Electronic address: jtaneera@sharjah.ac.ae.
Mohammed I; Department of Clinical Science, UMAS, Clinical Research Center, Lund University, Malmö, Sweden.
Mohammed AK; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Hachim M; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Dhaiban S; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Malek A; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Dunér P; Department of Clinical Science, UMAS, Clinical Research Center, Lund University, Malmö, Sweden.
Elemam NM; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Sulaiman N; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Hamad M; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates; Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Salehi A; Department of Clinical Science, UMAS, Clinical Research Center, Lund University, Malmö, Sweden; Department of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Gothenburg, Sweden. Electronic address: s_albert.salehi@med.lu.se.

Mol Cell Endocrinol ; 499: 110592, 2020 01 01.

Article en En | MEDLINE | ID: mdl-31550518

Asunto(s)

Diabetes Mellitus Tipo 2/metabolismo; Hidroxicolesteroles/farmacología; Células Secretoras de Insulina/citología; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Anciano; Línea Celular; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Diabetes Mellitus Tipo 2/genética; Femenino; Perfilación de la Expresión Génica; Humanos; Secreción de Insulina; Células Secretoras de Insulina/metabolismo; Masculino; Persona de Mediana Edad; Análisis de Secuencia por Matrices de Oligonucleótidos; Transducción de Señal

Palabras clave

7α-25-DHC; GPCRs; GPR183; Microarray gene expression; RNA-Sequencing; Type 2 diabetes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Hidroxicolesteroles Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Cell Endocrinol Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda

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