[The expression and function of acid-sensing ion channels in auditory system and vestibular system].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 54(9): 708-711, 2019 Sep 07.
Article
en Zh
| MEDLINE
| ID: mdl-31550769
ABSTRACT
Acid-sensing ion channels are a class of extracellular H(+) activated cation channels, belonging to the amiloride-sensitive epithelial Na(+) channel/degenerin (ENaC/DEG) superfamily. During extracellular acidification, the channels are activated and produce corresponding action potential. Acid-sensing ion channels are extensively expressed in the peripheral and central nervous system. It plays an important in synaptic plasticity, mechanical sensation, injury sensation related to acidosis of local tissues, acid reception and retinal regulation. This article reviews the expression, biological characteristics and functions of acid-sensing ion channels in cochlea, vestibular tissue and auditory center, so as to improve the understanding of physiology and pathophysiology of auditory system.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corteza Auditiva
/
Vestíbulo del Laberinto
/
Cóclea
/
Canales Iónicos Sensibles al Ácido
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Año:
2019
Tipo del documento:
Article
País de afiliación:
China