Application of the genetic risk model for the analysis of predisposition to nonlacunar ischemic stroke.
Per Med
; 16(5): 369-378, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31552798
ABSTRACT
Aim:
The purpose of our study was to analyze the predictive ability of the multiplicative model of genetic risk of nonlacunar ischemic stroke (IS) for independent samples from Russia. Patients &methods:
A total of 181 patients and 360 healthy controls were included in this study. The discriminative accuracy of model was evaluated by the area under the receiver operating characteristic curve (AUC).Results:
Classification model based on 15 single-nucleotide polymorphisms (SNPs), which are associated with a cardioembolic subtype of IS, had an AUC of 0.62 in patients with corresponding subtypes and an AUC of 0.58 for all patients.Conclusion:
Risk calculation approach based on IS-associated SNPs had satisfactory performance in predicting the predisposition to the disease.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Isquemia Encefálica
/
Pruebas Genéticas
/
Accidente Cerebrovascular
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
/
Europa
Idioma:
En
Revista:
Per Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia