Your browser doesn't support javascript.
loading
Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome.
Peiró, Óscar M; Farré, Nuria; Cediel, German; Bonet, Gil; Rojas, Sergio; Quintern, Verónica; Bardají, Alfredo.
Afiliación
  • Peiró ÓM; Department of Cardiology, Joan XXIII University Hospital, Tarragona, Spain.
  • Farré N; Pere Virgili Health Research Institute, Rovira i Virgili University, Tarragona, Spain.
  • Cediel G; Heart Failure Unit, Department of Cardiology, Hospital del Mar, Barcelona, Spain.
  • Bonet G; Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
  • Rojas S; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Quintern V; Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
  • Bardají A; Department of Cardiology, Joan XXIII University Hospital, Tarragona, Spain.
Biomark Med ; 13(14): 1187-1198, 2019 10.
Article en En | MEDLINE | ID: mdl-31559838
Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Coronario Agudo / Quimiocina CXCL12 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Coronario Agudo / Quimiocina CXCL12 Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido