[Comparative analysis of immune response indices in lung cancer]. / Sravnitel'nyi analiz pokazatelei immunologicheskoi reaktivnosti pri rake legkogo.
Vopr Onkol
; 31(1): 39-44, 1985.
Article
en Ru
| MEDLINE
| ID: mdl-3156450
ABSTRACT
In 43 patients with cancer of the lung, a number of immunologic indexes were evaluated including lymphocyte response to PHA, lymphokine production, serum immunoglobulin levels and the regulatory effect of sera and T-lymphocytes on lymphokine production. No significant deficiency in T- and B-lymphocytes was registered in patients with stage I-III cancer, nor any rise in TG cell level was in evidence. The response to PHA was low; however, the capacity to produce lymphokines in the presence of allogeneic or autologous tumor antigens was unimpaired. Purified T- and TG-cells isolated from blood or tumor tissue suppressed immune response in leukocyte migration inhibition test. However, this effect was not related to the increase in levels of these cells in the circulation. The autologous sera of practically all tumor-sensitized patients exerted a blocking effect in vitro. This effect was related neither to levels of serum immunoglobulins, nor to those of blood TG cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pulmonares
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
Ru
Revista:
Vopr Onkol
Año:
1985
Tipo del documento:
Article