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Pharmacological profile of vascular activity of human stem villous arteries.
Sander, Katrin N; Ali, Tayyba Y; Warren, Averil Y; Hay, Daniel P; Broughton Pipkin, Fiona; Barrett, David A; Khan, Raheela N.
Afiliación
  • Sander KN; Division of Medical Science and Graduate Entry Medicine, School of Medicine, University of Nottingham, The Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT, UK; Advanced Materials and Healthcare Technologies Division, Centre for Analytical Bioscience, School of Pharmacy, University of Nottingha
  • Ali TY; Division of Medical Science and Graduate Entry Medicine, School of Medicine, University of Nottingham, The Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT, UK.
  • Warren AY; Division of Medical Science and Graduate Entry Medicine, School of Medicine, University of Nottingham, The Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT, UK.
  • Hay DP; Division of Medical Science and Graduate Entry Medicine, School of Medicine, University of Nottingham, The Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT, UK.
  • Broughton Pipkin F; Division of Child Health, Obstetrics and Gynaecology, School of Medicine, City Hospital, Maternity Unit, Hucknall Road, Nottingham NG5 1PB, UK.
  • Barrett DA; Advanced Materials and Healthcare Technologies Division, Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Khan RN; Division of Medical Science and Graduate Entry Medicine, School of Medicine, University of Nottingham, The Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT, UK. Electronic address: raheela.khan@nottingham.ac.uk.
Placenta ; 88: 12-19, 2019 12.
Article en En | MEDLINE | ID: mdl-31574379
INTRODUCTION: The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed conditions potentially leading to placental dysfunction. METHODS: Behaviour of human stem villous arteries isolated from placentae at term pregnancy was assessed using wire myography. Effects of a selection of known vasoconstrictors and vasodilators of the systemic vasculature were assessed. The morphology of stem villous arteries was examined using IHC and TEM. RESULTS: Contractile effects in stem villous arteries were caused by U46619, 5-HT, angiotensin II and endothelin-1 (p ≤ 0.05), whereas noradrenaline and AVP failed to result in a contraction. Dilating effects were seen for histamine, riluzole, nifedipine, papaverine, SNP and SQ29548 (p ≤ 0.05) but not for acetylcholine, bradykinin and substance P. DISCUSSION: Stem villous arteries behave differently to vessels of the systemic vasculature and results indicate that the placenta is cut off from the systemic maternal vascular regulation. Particularly, endothelium-dependent processes were attenuated in the placental vasculature, creating a need to determine the role of the endothelium in the placenta in future studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Arterias / Vasoconstrictores / Vasodilatadores Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Placenta Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Arterias / Vasoconstrictores / Vasodilatadores Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Placenta Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos