Asymmetric dimethylarginine aggravates blood-retinal barrier breakdown of diabetic retinopathy via inhibition of intercellular communication in retinal pericytes.

Huang, Chu-Yi; Zhou, Ting; Li, Ge; Li, Ming-Yuan; Xiong, Xiao-Ming; Wu, Mei-Ting; Jiang, Jun-Lin

Huang, Chu-Yi; Zhou, Ting; Li, Ge; Li, Ming-Yuan; Xiong, Xiao-Ming; Wu, Mei-Ting; Jiang, Jun-Lin.

Afiliación

Huang CY; Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, No. 110 Xiangya Road, Changsha, 410078, Hunan, People's Republic of China.
Zhou T; Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, No. 110 Xiangya Road, Changsha, 410078, Hunan, People's Republic of China.
Li G; Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, No. 110 Xiangya Road, Changsha, 410078, Hunan, People's Republic of China.
Li MY; Faculty of Medical Public Courses, Xinhua College of Sun Yat-sen University, Guangzhou, 510520, Guangdong, People's Republic of China.
Xiong XM; Department of Ophthalmology, Xiangya Third Hospital, Central South University, Changsha, 410008, People's Republic of China.
Wu MT; Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, No. 110 Xiangya Road, Changsha, 410078, Hunan, People's Republic of China.
Jiang JL; Hunan Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha, 410078, Hunan, People's Republic of China.

Amino Acids ; 51(10-12): 1515-1526, 2019 Nov.

Article en En | MEDLINE | ID: mdl-31576457

Asunto(s)

Arginina/análogos & derivados; Barrera Hematorretinal/patología; Diabetes Mellitus Experimental/patología; Retinopatía Diabética/patología; Pericitos/patología; Animales; Apoptosis; Arginina/metabolismo; Barrera Hematorretinal/metabolismo; Comunicación Celular; Permeabilidad de la Membrana Celular; Células Cultivadas; Conexina 43/metabolismo; Diabetes Mellitus Experimental/inducido químicamente; Diabetes Mellitus Experimental/metabolismo; Retinopatía Diabética/inducido químicamente; Retinopatía Diabética/metabolismo; Uniones Comunicantes/patología; Glucosa/metabolismo; Masculino; Pericitos/metabolismo; Ratas; Ratas Sprague-Dawley; Estreptozocina/administración & dosificación; Estreptozocina/toxicidad

Palabras clave

Asymmetric dimethylarginine; Connexin 43; Diabetic retinopathy; Gap junction intercellular communication; bloodretinal barrier dysfunction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Barrera Hematorretinal / Pericitos / Diabetes Mellitus Experimental / Retinopatía Diabética Límite: Animals Idioma: En Revista: Amino Acids Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article

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