The More the Merrier: When Four Interfaces Are Better Than One.
Structure
; 27(10): 1483-1484, 2019 10 01.
Article
en En
| MEDLINE
| ID: mdl-31577936
ABSTRACT
In this issue of Structure, Zhou et al. (2019) determine the crystal and solution structures of iASPP bound to PP1. The proteins interact through a discontinuous interface defined by four contact points. Association/dissociation of individual contacts enables the transition between multiple conformations and provides mechanistic insight into how ASPPs regulate phosphorylation of p53.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas
Idioma:
En
Revista:
Structure
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2019
Tipo del documento:
Article