Autoactivation of small GTPases by the GEF-effector positive feedback modules.
F1000Res
; 82019.
Article
en En
| MEDLINE
| ID: mdl-31583084
ABSTRACT
Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Remarkably, in some systems, the upstream regulators of GTPases are also found downstream of their activity. Resulting feedback loops can generate complex spatiotemporal dynamics of GTPases with important functional consequences. Here we discuss the concept of positive autoregulation of small GTPases by the GEF-effector feedback modules and survey recent developments in this exciting area of cell biology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al GTP Monoméricas
/
Proteínas Activadoras de GTPasa
/
Factores de Intercambio de Guanina Nucleótido
Límite:
Humans
Idioma:
En
Revista:
F1000Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Reino Unido