High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.

Clement, Helen A; Boghi, Michele; McDonald, Rory M; Bernier, Louise; Coe, Jotham W; Farrell, William; Helal, Christopher J; Reese, Matthew R; Sach, Neal W; Lee, Jack C; Hall, Dennis G

Clement, Helen A; Boghi, Michele; McDonald, Rory M; Bernier, Louise; Coe, Jotham W; Farrell, William; Helal, Christopher J; Reese, Matthew R; Sach, Neal W; Lee, Jack C; Hall, Dennis G.

Afiliación

Clement HA; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
Boghi M; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
McDonald RM; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
Bernier L; Pfizer Worldwide Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, CA, 92121, USA.
Coe JW; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT, 06340, USA.
Farrell W; Pfizer Worldwide Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, CA, 92121, USA.
Helal CJ; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT, 06340, USA.
Reese MR; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT, 06340, USA.
Sach NW; Pfizer Worldwide Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, CA, 92121, USA.
Lee JC; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT, 06340, USA.
Hall DG; Department of Chemistry, 4-010 CCIS, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.

Angew Chem Int Ed Engl ; 58(51): 18405-18409, 2019 12 16.

Article en En | MEDLINE | ID: mdl-31591755

Palabras clave

asymmetric catalysis; conjugate borylation; cyclobutanones; cyclobutenones; cyclobutylboronates

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: Angew Chem Int Ed Engl Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania

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