Prognostic Classification of Multiple Primary Lung Cancers Based on a Ground-Glass Opacity Component.
Ann Thorac Surg
; 109(2): 420-427, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31593656
ABSTRACT
BACKGROUND:
We evaluated the prognostic impact of the presence of a ground-glass opacity (GGO) component on thin-section computed tomography for the refined clinical T classification of multiple primary lung cancers.METHODS:
We reviewed 272 surgically resected, clinically node-negative multiple lung cancers. Dominant tumors were classified into 2 groups based on the presence of a GGO component; that is, a GGO tumor (consolidation tumor ratio, 0 to <1.0) or pure-solid (PS) tumor (consolidation tumor ratio, 1.0). Furthermore, multifocal GGOs (MFGGOs) were defined as lesions showing a GGO component for all tumors. Their prognoses were evaluated using Cox proportional hazard model.RESULTS:
There were 153 MFGGOs (56%) with a significantly better 5-year overall survival than non-MFGGOs (97.2% vs 68.5%, P < .001). A multivariable analysis revealed that MFGGO and absence of nodal involvement were independently significant prognosticators of better survival (P = .007 and P = .012, respectively). Furthermore, among the patients of non-MFGGO groups, multivariate analysis showed that a PS + PS pattern and presence of nodal involvement were independently significant prognosticators of poorer survival (P = .008 and P = .001, respectively). We divided the tumors into 3 groups based on the results and focusing on the presence of a GGO; that is, MFGGO (n = 153), PS + additional GGO (n = 81), and PS + PS (n = 38). The 5-year overall survival was clearly split among them MFGGO, 97.2%; PS + additional GGO, 82.1%; and PS + PS, 41.3% (P < .001).CONCLUSIONS:
Our results suggest that presence of a GGO component has the ability to distinguish the survival even for multiple lung cancers. Further investigations including multicenter trials are certainly warranted to address the revision of T variable of multiple lung cancers considering a presence of GGO component.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neumonectomía
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Carcinoma de Pulmón de Células no Pequeñas
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Neoplasias Pulmonares
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Neoplasias Primarias Múltiples
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Ann Thorac Surg
Año:
2020
Tipo del documento:
Article