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A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease.
Burbulla, Lena F; Jeon, Sohee; Zheng, Jianbin; Song, Pingping; Silverman, Richard B; Krainc, Dimitri.
Afiliación
  • Burbulla LF; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Jeon S; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Zheng J; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Song P; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, IL 60208, USA.
  • Silverman RB; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Krainc D; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, IL 60208, USA.
Sci Transl Med ; 11(514)2019 10 16.
Article en En | MEDLINE | ID: mdl-31619543
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Glucosilceramidasa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Glucosilceramidasa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos