Preparation, characterization, and evaluation of the anticancer activity of artemether-loaded nano-niosomes against breast cancer.
Breast Cancer
; 27(2): 243-251, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31621052
ABSTRACT
BACKGROUND:
The aim of this study was to develop nonionic surfactant vesicles (niosomes) as a promising nanocarrier to enhance the anticancer activity of artemether.METHODS:
The niosomes were prepared by thin-film hydration method containing a mixture of Span, Tween and cholesterol (Chol) in different molar ratios. All formulations were characterized in terms of size, entrapment efficiency (%EE), release profile and morphology. The optimized niosomal formulation (F7), artemether and phosphate buffered saline (PBS) were intratumorally administrated to mice as the nano-niosome group, the free drug group and the control group, respectively (n = 4 per group). Tumor volume was measured during the 12-day experiment, then mice were sacrificed to evaluate the necrosis, angiogenesis, and cell proliferation of tumor tissues by H&E, CD34 and Ki-67 immunostaining, respectively.RESULTS:
Both artemether and nano-niosome groups could decrease angiogenesis and proliferation of tumor cells. However, in nano-niosome group superior tumor necrosis and smaller tumor volume were observed compared to both artemether and control groups.CONCLUSIONS:
The niosomal formulation could be a promising carrier for breast cancer treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Arteméter
Límite:
Animals
/
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Breast Cancer
Asunto de la revista:
NEOPLASIAS
Año:
2020
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
JAPAN
/
JAPON
/
JAPÃO
/
JP