[The pegylated form of interferon beta in the treatment of multiple sclerosis]. / Pegilirovannaia forma interferona beta v terapii rasseiannogo skleroza.

ABSTRACT

Interferons-beta (IFN-ß) along with glatiramer acetate is one of the most commonly used disease modifying treatment (DMT) of multiple sclerosis (MS) associated with effectiveness and acceptable safety profile. At the same time, therapy with IFN-ß has a number of limitations associated with a high frequency of injections and production of neutralizing antibodies. The development of the pegylated form of IFN-ß (PEG-IFN-ß) is aimed at resolving these issues. This article reviewed the mechanism of action, efficacy, safety and tolerability of PEG-IFN-ß in the treatment of MS.