Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT<sub>1A</sub>/5-HT<sub>7</sub>.

Gu, Zheng-Song; Wang, Wen-Tao; Qian, Hao; Zhou, Ai-Nan; Sun, Hong-Bin; Zhang, Qing-Wei; Li, Jian-Qi

Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT_1A/5-HT₇.

Gu, Zheng-Song; Wang, Wen-Tao; Qian, Hao; Zhou, Ai-Nan; Sun, Hong-Bin; Zhang, Qing-Wei; Li, Jian-Qi.

Afiliación

Gu ZS; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, PR China.
Wang WT; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, PR China; School of Engineering, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, PR China.
Qian H; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, PR China.
Zhou AN; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, PR China.
Sun HB; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, PR China.
Zhang QW; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, PR China. Electronic address: sipiqingwei@163.com.
Li JQ; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, PR China. Electronic address: lijianqb@126.com.

Bioorg Med Chem Lett ; 29(23): 126703, 2019 12 01.

Article en En | MEDLINE | ID: mdl-31627993

Asunto(s)

Antidepresivos/uso terapéutico; Piperazina/uso terapéutico; Piperidinas/uso terapéutico; Inhibidores Selectivos de la Recaptación de Serotonina/uso terapéutico; Antidepresivos/farmacología; Humanos; Piperazina/farmacología; Piperidinas/farmacología; Inhibidores Selectivos de la Recaptación de Serotonina/farmacología; Relación Estructura-Actividad

Palabras clave

5-HT(1A) receptor; 5-HT(7) receptor; Antidepressant; Serotonin reuptake inhibition

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Inhibidores Selectivos de la Recaptación de Serotonina / Piperazina / Antidepresivos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article

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