A systematic review and meta-analysis: Memantine augmentation in moderate to severe obsessive-compulsive disorder.
Psychiatry Res
; 282: 112602, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31630042
ABSTRACT
A considerable proportion of obsessive-compulsive disorder (OCD) patients receiving first-line pharmacological therapy, fail to fully respond to treatment and continue to exhibit significant symptoms. In this systematic review, we evaluate the efficacy of memantine, as a glutamate-modulating agent, in moderate to severe OCD. Single and double blinded as well as open-label trials of memantine augmentation in adults with OCD were considered. Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores were the primary outcome measure. The electronic databases of PubMed, Scopus, Embase and Google Scholar were searched for relevant trials using keywords 'obsessive-compulsive disorder OR OCD' AND 'memantine'. The meta-analysis of eight studies involving 125 OCD subjects receiving memantine augmentation exhibited a significant overall mean reduction of 11.73 points in Y-BOCS scores. The categorical analysis of treatment response (a minimum of 35% reduction in Y-BOCS) in four double-blind placebo-controlled studies indicated that OCD patients receiving memantine augmentation were 3.61 times more likely to respond to treatment than those receiving placebo. We found that 20â¯mg/day memantine augmentation to first-line pharmacological treatment for a period of at least 8 weeks is a safe and effective intervention for moderate to severe OCD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Memantina
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Antagonistas de Aminoácidos Excitadores
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Trastorno Obsesivo Compulsivo
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Psychiatry Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Irán