[Research progress on neural mechanism of peripheral inflammation in Parkinson's disease].
Sheng Li Xue Bao
; 71(5): 732-740, 2019 Oct 25.
Article
en Zh
| MEDLINE
| ID: mdl-31646327
ABSTRACT
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by loss of dopaminergic (DA) neurons in the dense part of the substantia nigra (SNpc). Postmortem analysis of PD patients and experimental animal studies found that microglial cell activation and increased levels of pro-inflammatory factors were common features of PD brain tissue. At the same time, the invasion and accumulation of peripheric immune cells were detected in the brain of PD patients. In this paper, peripheral inflammation across the blood-brain barrier (BBB), the misfolded α-synuclein (α-syn)-induced microglial cell activation and intracerebral inflammation in PD are summarized, providing potential therapeutic measures for delaying the onset of PD.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Sustancia Negra
/
Inflamación
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2019
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA