Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.
Magn Reson Imaging
; 65: 100-108, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31655139
ABSTRACT
OBJECTIVES:
To assess the feasibility of ferumoxytol-enhanced MRI in pregnancy with a nonhuman primate model. MATERIALS ANDMETHODS:
In this prospective study, eleven pregnant rhesus macaques at day 98⯱â¯5 of gestation were divided into three groups, untreated control (UC) (nâ¯=â¯3), saline control (SC) (nâ¯=â¯4) and interleukin 1 beta (IL-1ß) treated (IT) (nâ¯=â¯4), which were administered with either saline or IL-1ß into the amniotic fluid. All animals were imaged at multiple time points before and after ferumoxytol administration (4â¯mg/kg). Longitudinal R2* and susceptibility of tissues were obtained using region-of-interest analysis and the longitudinal changes were assessed using linear mixed models and Student's t-test.RESULTS:
In fetuses, a slope of 0.3â¯s-1/day (Pâ¯=â¯0.008), 0.00â¯ppm/day (Pâ¯=â¯0.699) and -â¯0.2â¯s-1/day (Pâ¯=â¯0.023) was observed in liver R2*, liver susceptibility, and lung R2*, respectively. In placentas, R2* and susceptibility increased immediately after ferumoxytol administration (Pâ¯<â¯0.001) and decreased to baseline within two days. The mean change from baseline showed no significant difference between the SC group and the IT group at all scan time points. In maternal livers, R2* increased immediately after ferumoxytol administration, further increased at one-day, and then decreased but remained elevated (Pâ¯<â¯0.001). The mean change from baseline showed no significant difference between the SC group and the IT group at all scan time points.CONCLUSIONS:
This work demonstrates the feasibility of quantitative ferumoxytol-enhanced MRI to measure dynamics of ferumoxytol delivery and washout in the placenta. Stable MRI measurements indicated no evidence of iron deposition in fetal tissues of nonhuman primates after maternal ferumoxytol exposure.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Preñez
/
Imagen por Resonancia Magnética
/
Medios de Contraste
/
Óxido Ferrosoférrico
Tipo de estudio:
Observational_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Magn Reson Imaging
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos