Bioactive acetaminophen derivatives from Penicillum herquei JX4.
Fitoterapia
; 139: 104400, 2019 Nov.
Article
en En
| MEDLINE
| ID: mdl-31669962
ABSTRACT
Two novel epimer pairs of acetaminophen derivatives penicilquei A-D (1-4) were isolated from Penicillium herquei JX4. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of penicilquei A-D (1-4) were determined by modifified Mosher's method, and comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Penicilquei A-D (1-4) are the first example of acetaminophen derivatives featuring an unprecedented carbon skeleton. The inhibitory activities of all compounds against nine phytopathogenic fungi and α-glucosidase were evaluated. Penicilquei A-D (1-4) showed strong inhibitory activities against at least eight phytopathogenic fungus.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Penicillium
/
Fungicidas Industriales
/
Acetaminofén
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2019
Tipo del documento:
Article