Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-ß) in children with autism spectrum disorder.
J Neuroimmunol
; 337: 577071, 2019 12 15.
Article
en En
| MEDLINE
| ID: mdl-31671361
ABSTRACT
We aimed in this study to investigate a possible involvement of Th17/Treg cells imbalance in autism spectrum disorders (ASD). Using flowcytometry to determine circulating Th17 and Treg cells percentages, RT- PCR and ELISA for cytokine expression, we demonstrated that Th17/Treg balance in ASD children was significantly skewed toward a Th17 response compared to their control. Th17 cells and the ratio of Th17/Treg cells had a significantly positive correlation with disease severity whereas Treg cells had a negative correlation. The imbalance of Th17, Treg cells and their related cytokines may play a vital role in the progression of the disease.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de Crecimiento Transformador beta
/
Interleucina-10
/
Linfocitos T Reguladores
/
Interleucina-17
/
Células Th17
/
Trastorno del Espectro Autista
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Año:
2019
Tipo del documento:
Article