PET [11C]acetate is also a perfusion tracer for kidney evaluation purposes.
Nucl Med Biol
; 76-77: 10-14, 2019.
Article
en En
| MEDLINE
| ID: mdl-31675615
ABSTRACT
RATIONALE Renal positron emission tomography (PET) functional imaging allows non-invasive and dynamic measurements of functional and metabolic parameters. [15O]H2O is used as a perfusion tracer, and [11C]acetate as an oxidative metabolism in this purpose, requiring two injections to assess those fundamental parameters. Yet, in cardiac physiology study, the high first-pass myocardial extraction fraction of [11C]acetate allowed to use its influx rate as a blood flow marker too. Since [11C]acetate has been characterized by a 20-25% single pass renal extraction in dogs, it could be used as a potential tracer for renal perfusion. The aim of this study was to determine whether [11C]acetate influx rate can be used as quantitative in vivo marker of kidney perfusion in human. METHODS:
In 10 healthy subjects, dynamic PET acquisitions were performed after [15O]H2O and [11C]acetate injections spaced by a 15-minute interval. As previously validated, with compartmental modeling of kinetics, renal perfusion and oxidative metabolism were estimated respectively with influx rate of [15O]H2O and efflux rate of [11C]acetate. Additionally, influx rate of [11C]acetate was regressed to influx rate of [15O]H2O.RESULTS:
Renal time activity curves of [11C]-acetate was best fitted with a mono compartmental model compared to a bi-compartmental model (pâ¯<â¯0.0001). [11C]acetate influx rate was significantly correlated with perfusion quantified with [15O]H2O (r2â¯=â¯0.37, pâ¯<â¯0.001) at baseline. This regression allowed the computation of a renal [11C]acetate extraction fraction (EF), and further the computation of renal blood flow from its influx rate.CONCLUSION:
In healthy subjects, over a wide range of renal perfusion, direct estimates of renal oxygen consumption as well as tissue perfusion can be obtained by PET with a single tracer [11C]acetate. This approach needs to be validated in CKD patients, and would be of great interest to design clinical protocol aiming at evaluating ischemic nephropathies candidate to revascularization.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flujo Sanguíneo Regional
/
Radioisótopos de Carbono
/
Tomografía de Emisión de Positrones
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Riñón
/
Acetatos
Tipo de estudio:
Guideline
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Nucl Med Biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA NUCLEAR
Año:
2019
Tipo del documento:
Article