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Association of brachial and central hemodynamic parameters to eGFR and proteinuria in Gujarati diabetics with mild-to-moderate nephropathy.
Solanki, Jayesh D; Patel, Rajkumar B; Hadiyel, Ila N; Mehta, Hemant B; Munshi, Hirava B; Kakadiya, Param J.
Afiliación
  • Solanki JD; Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
  • Patel RB; Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
  • Hadiyel IN; Department of Medicine, Government Medical College, Bhavnagar, Gujarat, India.
  • Mehta HB; Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
  • Munshi HB; Department of Medicine, Government Medical College, Bhavnagar, Gujarat, India.
  • Kakadiya PJ; Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
J Family Med Prim Care ; 8(9): 2965-2970, 2019 Sep.
Article en En | MEDLINE | ID: mdl-31681676
INTRODUCTION: Diabetes mellitus (DM) is a significant risk factor for nephropathy and cardiovascular morbidity. Pulse wave analysis (PWA) gives direct inference of brachial hemodynamics (BH) and central hemodynamics (CH). We studied relation of them with diabetic nephropathy (DN) among type-2 diabetics (T2D). METHODS: We studied oscillometric PWA by a cross-sectional study in 160 T2Ds. Using Mobil-o-Graph (IEM, Germany), we derived BH (blood pressure, pulse pressure index, rate pressure product) and CH (aortic pressure, cardiac index, stroke volume index, stroke work). They were further compared and associated with DN in terms of creatinine, proteinuria, and estimated glomerular filtration rate (eGFR). RESULTS: There were 89 males, mean age 56 years, mean duration 4.8 years, 80% hypertensive predominantly using ACE inhibitors, poor glycemic blood pressure (BP) control, mainly mild-to-moderate DN, mean eGFR 88.2, 34% prevalence of proteinuria. Arterial stiffness was high with female disadvantage. BH and CH parameters were not different with or without DN using proteinuria or eGFR (60 cutoff) criteria. BH, CH correlated insignificantly with creatinine and eGFR. Female disadvantage, correlation with bSBP and aSBP were only significant results. CONCLUSIONS: BH and CH are not related to eGFR and proteinuria in predominantly hypertensive, Gujarati diabetics with mild-to-moderate nephropathy suggesting need of other cardiovascular parameters.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: J Family Med Prim Care Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: J Family Med Prim Care Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: India