Antipsychotic drugs in epilepsy.
Neurol Neurochir Pol
; 53(6): 408-412, 2019.
Article
en En
| MEDLINE
| ID: mdl-31681966
ABSTRACT
The prevalence of various psychiatric disorders in people with epilepsy is high, with psychoses affecting 2-9% of patients. Antipsychotic drugs have been identified as increasing the risk of epileptic seizures. For first-generation antipsychotics such a risk appears to be relatively low, with the exception of chlorpromazine. Among second-generation antipsychotics, clozapine use carries the highest risk of seizure induction, while risperidone, quetiapine, amisulpride, and aripiprazole seem to pose a significantly lower risk. The incidence of an increased number of seizures is linked to the elevated blood plasma level effect of antipsychotics. To diminish the risk of seizures, it is important to start with a small dose of antipsychotic drug, to titrate slowly, to monitor serum levels of prescribed drugs, and to keep the drug at the minimal effective dose.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antipsicóticos
/
Epilepsia
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Neurol Neurochir Pol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Polonia