[Analysis of clinical characteristics and risk factors of cytomegalovirus reactivation in immunocompetent patients in respiratory intensive care unit].
Zhonghua Yi Xue Za Zhi
; 99(40): 3168-3171, 2019 Oct 29.
Article
en Zh
| MEDLINE
| ID: mdl-31694109
ABSTRACT
Objective:
To investigate the clinical characteristics and risk factors of cytomegalovirus (CMV) reactivation in immunocompetent patients in respiratory intensive care unit (RICU).Methods:
Clinical data of immunocompetent patients whose serum CMV-DNA was monitored during hospitalization in the RICU of Peking University First Hospital from July 2014 to July 2018 were collected and reviewed in this retrospective study. Patients were divided into the CMV reactivation group and non reactivation group. Demographics, clinical features, and outcomes of patients in the two groups were analyzed. The multivariable logistic regression analysis was used to analyze the independent risk factors for CMV reactivation.Results:
Of the 81 patients, 11 (13.6%) were in the reactivation group and 70 (86.4%) were in the non reactivation group. Length of RICU stay were longer in the group with CMV reactivation compared to patients without CMV reactivation [54(50, 68) vs 32(17, 43) d, P=0.012]. Baseline demographic and disease characteristics, rate of ventilator-associated pneumonia, duration of mechanical ventilation and mortality were similar in the two groups. Multivariable logistic regression analysis showed that blood transfusion (OR=11.481, 95%CI 1.154-114.201; P=0.037) and corticosteroids use (OR=13.952, 95%CI 2.301-84.609; P=0.004) were independent risk factors for CMV reactivation.Conclusions:
CMV reactivation is associated with a longer stay in the RICU in immunocompetent patients, blood transfusion and corticosteroids use constitute risk factors.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Citomegalovirus
/
Citomegalovirus
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Año:
2019
Tipo del documento:
Article
País de afiliación:
China