Advances toward Curing HIV-1 Infection in Tissue Reservoirs.
J Virol
; 94(3)2020 01 17.
Article
en En
| MEDLINE
| ID: mdl-31694954
ABSTRACT
A disease of more than 39.6 million people worldwide, HIV-1 infection has no curative therapy. To date, one man has achieved a sterile cure, with millions more hoping to avoid the potential pitfalls of lifelong antiretroviral therapy and other HIV-related disorders, including neurocognitive decline. Recent developments in immunotherapies and gene therapies provide renewed hope in advancing efforts toward a sterilizing or functional cure. On the horizon is research concentrated in multiple separate but potentially complementary domains vaccine research, viral transcript editing, T-cell effector response targeting including checkpoint inhibitors, and gene editing. Here, we review the concept of targeting the HIV-1 tissue reservoirs, with an emphasis on the central nervous system, and describe relevant new work in functional cure research and strategies for HIV-1 eradication.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reservorios de Enfermedades
/
Infecciones por VIH
/
VIH-1
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos