Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition.
Nat Prod Res
; 35(18): 3095-3099, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-31698954
ABSTRACT
Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against α-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Própolis
/
Alfa-Amilasas
/
Inhibidores de Glicósido Hidrolasas
/
Antioxidantes
País/Región como asunto:
Africa
Idioma:
En
Revista:
Nat Prod Res
Año:
2021
Tipo del documento:
Article
País de afiliación:
Nigeria