Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction.
Bull Exp Biol Med
; 167(5): 634-636, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31705224
ABSTRACT
Anti-ischemic activity of fabomotizole hydrochloride was studied on the model of subendocardial ischemia in rats with endothelial dysfunction. Endothelial dysfunction was modeled by intragastric administration of methionine (3 g/kg, once a day for 7 days). Acute subendocardial ischemia was induced in narcotized rats by intraperitoneal injection of isoproterenol (20 µg/kg/min over 5 min). Fabomotizole hydrochloride (intraperitoneally, 15 mg/kg) significantly reduced isoproterenol-induced ST segment depression in animals with endothelial dysfunction and with intact vasculature.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bencimidazoles
/
Endotelio Vascular
/
Cardiotónicos
/
Morfolinas
/
Isquemia Miocárdica
/
Endocardio
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia