Disrupted Visual Cortex Neurophysiology Following Very Preterm Birth.
Biol Psychiatry Cogn Neurosci Neuroimaging
; 5(10): 951-960, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-31706907
ABSTRACT
BACKGROUND:
Visual regions develop rapidly in utero and throughout early childhood, but very preterm (VPT) birth can disrupt the typical maturation of primary cortices, with VPT children exhibiting mild visual impairments in early life and throughout development. This is thought to be due to dysfunctional maturation of occipital cortices. A way to readily index brain function is to examine neural oscillations; these mechanisms play a central role in the modeling and pruning of connections, providing an intrinsic temporal structure that refines the precise alignment of spiking, processing information in the brain, and coordinating networks.METHODS:
Using magnetoencephalography, we examined regional oscillatory patterns and functional coupling in VPT and full-term children. Five minutes of eyes-open resting-state data were acquired from 27 VPT and 32 full-term children at 8 years of age.RESULTS:
As hypothesized, the VPT group, when compared with control children, had elevated theta-band power, while alpha amplitude envelope coupling, a marker of connectivity, was found to be decreased.CONCLUSIONS:
These results support the hypothesis of spectral slowing in VPT children and more broadly suggest that the developmental arc of visual neurophysiology is disrupted by VPT birth. We conclude that these deficits underlie difficulties in complex visual perceptual processing evident during childhood and beyond.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corteza Visual
/
Nacimiento Prematuro
Límite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Biol Psychiatry Cogn Neurosci Neuroimaging
Año:
2020
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
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EUA
/
UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA