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Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.
Ide, Yuya; Horie, Takahiro; Saito, Naritatsu; Watanabe, Shin; Otani, Chiharu; Miyasaka, Yui; Kuwabara, Yasuhide; Nishino, Tomohiro; Nakao, Tetsushi; Nishiga, Masataka; Nishi, Hitoo; Nakashima, Yasuhiro; Nakazeki, Fumiko; Koyama, Satoshi; Kimura, Masahiro; Tsuji, Shuhei; Rodriguez, Randolph Ruiz; Xu, Sijia; Yamasaki, Tomohiro; Watanabe, Toshimitsu; Yamamoto, Masamichi; Yanagita, Motoko; Kimura, Takeshi; Kakizuka, Akira; Ono, Koh.
Afiliación
  • Ide Y; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Horie T; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Saito N; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Watanabe S; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Otani C; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Miyasaka Y; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kuwabara Y; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Nishino T; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Nakao T; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Nishiga M; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Nishi H; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Nakashima Y; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Nakazeki F; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Koyama S; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kimura M; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Tsuji S; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Rodriguez RR; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Xu S; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Yamasaki T; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Watanabe T; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Yamamoto M; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Yanagita M; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Kimura T; Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.
  • Kakizuka A; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Ono K; Laboratory of Functional Biology, Kyoto University Graduate School of Biostudies and Solution Oriented Research for Science and Technology, Kyoto, Japan.
JACC Basic Transl Sci ; 4(6): 701-714, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31709319
ABSTRACT
No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Año: 2019 Tipo del documento: Article País de afiliación: Japón