Real-time hyperpolarized <sup>13</sup>C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4-double knockout mouse livers.

Sharma, Gaurav; Wu, Cheng-Yang; Wynn, R Max; Gui, Wenjun; Malloy, Craig R; Sherry, A Dean; Chuang, David T; Khemtong, Chalermchai

Real-time hyperpolarized ¹³C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4-double knockout mouse livers.

Sharma, Gaurav; Wu, Cheng-Yang; Wynn, R Max; Gui, Wenjun; Malloy, Craig R; Sherry, A Dean; Chuang, David T; Khemtong, Chalermchai.

Afiliación

Sharma G; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Wu CY; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Wynn RM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Gui W; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Malloy CR; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Sherry AD; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Chuang DT; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Khemtong C; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Sci Rep ; 9(1): 16480, 2019 11 11.

Article en En | MEDLINE | ID: mdl-31712597

Asunto(s)

Espectroscopía de Resonancia Magnética con Carbono-13; Hígado/metabolismo; Oxidación-Reducción; Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/genética; Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/metabolismo; Ácido Pirúvico/metabolismo; Animales; Metabolismo de los Hidratos de Carbono; Carbohidratos/biosíntesis; Espectroscopía de Resonancia Magnética con Carbono-13/métodos; Hígado/patología; Redes y Vías Metabólicas; Ratones; Ratones Noqueados; Complejo Piruvato Deshidrogenasa/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Ácido Pirúvico / Espectroscopía de Resonancia Magnética con Carbono-13 / Piruvato Deshidrogenasa Quinasa Acetil-Transferidora / Hígado Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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