Abnormal linear growth in paediatric adrenal diseases: Pathogenesis, prevalence and management.
Clin Endocrinol (Oxf)
; 92(2): 98-108, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31747461
ABSTRACT
Abnormal adrenal function can interfere with linear growth, potentially causing either acceleration or impairment of growth in paediatric patients. These abnormalities can be caused by direct effects of adrenal hormones, particularly glucocorticoids and sex steroids, or be mediated by indirect mechanisms such as the disturbance of the growth hormone-insulin-like growth factor-1 axis and aromatization of androgens to oestrogens. The early diagnosis and optimal treatment of adrenal disorders can prevent or minimize growth disturbance and facilitate improved height gain. Mechanisms of growth disturbance in the following abnormal states will be discussed; hypercortisolaemia, hyperandrogenaemia and obesity. Prevalence and features of growth disturbance will be discussed in ACTH-dependent and ACTH-independent Cushing's syndrome, adrenocortical tumours, premature adrenarche, congenital adrenal hyperplasia and adrenal insufficiency disorders. Recommendations for management have been included.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de las Glándulas Suprarrenales
/
Trastornos del Crecimiento
Tipo de estudio:
Etiology_studies
/
Guideline
/
Prevalence_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Italia