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Disentangling the role of Africa in the global spread of H5 highly pathogenic avian influenza.
Fusaro, Alice; Zecchin, Bianca; Vrancken, Bram; Abolnik, Celia; Ademun, Rose; Alassane, Abdou; Arafa, Abdelsatar; Awuni, Joseph Adongo; Couacy-Hymann, Emmanuel; Coulibaly, M ' Bétiégué; Gaidet, Nicolas; Go-Maro, Emilie; Joannis, Tony; Jumbo, Simon Dickmu; Minoungou, Germaine; Meseko, Clement; Souley, Maman Moutari; Ndumu, Deo Birungi; Shittu, Ismaila; Twabela, Augustin; Wade, Abel; Wiersma, Lidewij; Akpeli, Yao P; Zamperin, Gianpiero; Milani, Adelaide; Lemey, Philippe; Monne, Isabella.
Afiliación
  • Fusaro A; Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy. afusaro@izsvenezie.it.
  • Zecchin B; Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Vrancken B; KU Leuven, Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.
  • Abolnik C; Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.
  • Ademun R; National Animal Disease Diagnostics and Epidemiology Center (NADDEC), Entebbe, Uganda.
  • Alassane A; Laboratoire Central de l'Elevage (LABOCEL), Niamey, Niger.
  • Arafa A; National Laboratory for Veterinary Quality Control on Poultry Production (NLQP), Animal Health Research Institute, Giza, Egypt.
  • Awuni JA; Accra Veterinary Laboratory, Accra, Ghana.
  • Couacy-Hymann E; Laboratoire Central de Pathologie Animale, Bingerville, Côte d'Ivoire.
  • Coulibaly M'B; Laboratoire National D'Appui au Développement Agricole, Abidjan, Côte d'Ivoire.
  • Gaidet N; CIRAD, UPR GREEN, Montpellier, France.
  • Go-Maro E; Laboratoire Central Vétérinaire de Lomé, Lomé, Togo.
  • Joannis T; National Veterinary Research Institute, Vom, Nigeria.
  • Jumbo SD; Laboratoire National Vétérinaire (LANAVET), Garoua, Cameroon.
  • Minoungou G; Laboratoire National d'Elevage de Ouagadougou, Ouagadougou, Burkina Faso.
  • Meseko C; National Veterinary Research Institute, Vom, Nigeria.
  • Souley MM; Laboratoire Central de l'Elevage (LABOCEL), Niamey, Niger.
  • Ndumu DB; National Animal Disease Diagnostics and Epidemiology Center (NADDEC), Entebbe, Uganda.
  • Shittu I; National Veterinary Research Institute, Vom, Nigeria.
  • Twabela A; Veterinary Laboratory of Kinshasa, Kinshasa, Democratic Republic of the Congo.
  • Wade A; Laboratoire National Vétérinaire (LANAVET), Yaoundé, Cameroon.
  • Wiersma L; Laboratory Unit of the Emergency Prevention System (EMPRES), Food and Agriculture Organization of the United Nations (UN-FAO), Rome, Italy.
  • Akpeli YP; Laboratoire Central Vétérinaire de Lomé, Lomé, Togo.
  • Zamperin G; Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Milani A; Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
  • Lemey P; KU Leuven, Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.
  • Monne I; Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy. imonne@izsvenezie.it.
Nat Commun ; 10(1): 5310, 2019 11 22.
Article en En | MEDLINE | ID: mdl-31757953
ABSTRACT
The role of Africa in the dynamics of the global spread of a zoonotic and economically-important virus, such as the highly pathogenic avian influenza (HPAI) H5Nx of the Gs/GD lineage, remains unexplored. Here we characterise the spatiotemporal patterns of virus diffusion during three HPAI H5Nx intercontinental epidemic waves and demonstrate that Africa mainly acted as an ecological sink of the HPAI H5Nx viruses. A joint analysis of host dynamics and continuous spatial diffusion indicates that poultry trade as well as wild bird migrations have contributed to the virus spreading into Africa, with West Africa acting as a crucial hotspot for virus introduction and dissemination into the continent. We demonstrate varying paths of avian influenza incursions into Africa as well as virus spread within Africa over time, which reveal that virus expansion is a complex phenomenon, shaped by an intricate interplay between avian host ecology, virus characteristics and environmental variables.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Gripe Humana / Gripe Aviar Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de las Aves de Corral / Gripe Humana / Gripe Aviar Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Italia