Hypochlorite-Induced Damage of Plasminogen Molecules: Structural-Functional Disturbance.
Dokl Biochem Biophys
; 488(1): 332-337, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31768854
ABSTRACT
Plasminogen, the precursor of plasmin, is a serine protease that plays a fundamental role in the intravascular thrombolysis. For the first time, by using high-resolution mass spectrometry, data on the oxidative modifications of the plasminogen molecule under induced oxidation were obtained. The FTIR data show that, under oxidation on the protein, its secondary structure also undergoes the rearrangements. The high tolerance of plasminogen to oxidation can be due to both the closed conformation and the ability of some Met residues to serve as ROS trap.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasminógeno
/
Ácido Hipocloroso
/
Modelos Químicos
Límite:
Humans
Idioma:
En
Revista:
Dokl Biochem Biophys
Asunto de la revista:
BIOFISICA
/
BIOQUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia