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Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer.
Kis, Brigitta; Ifrim, Feng Chen; Buda, Valentina; Avram, Stefana; Pavel, Ioana Zinuca; Antal, Diana; Paunescu, Virgil; Dehelean, Cristina Adriana; Ardelean, Florina; Diaconeasa, Zorita; Soica, Codruta; Danciu, Corina.
Afiliación
  • Kis B; Department of Pharmacognosy, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Ifrim FC; Centre for Gene and Cellular Therapies in the Treatment of Cancer- OncoGen, Clinical County Hospital of Timisoara, Liviu Rebreanu Blvd. 156, 300736 Timisoara, Romania.
  • Buda V; Department of Marketing, medical technology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Avram S; Department of Pharmacology and Clinical Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Pavel IZ; Department of Pharmacognosy, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Antal D; Department of Pharmacognosy, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Paunescu V; Department of Pharmaceutical Botany, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Dehelean CA; Centre for Gene and Cellular Therapies in the Treatment of Cancer- OncoGen, Clinical County Hospital of Timisoara, Liviu Rebreanu Blvd. 156, 300736 Timisoara, Romania.
  • Ardelean F; Department of Functional Sciences, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Diaconeasa Z; Department of Toxicology, "Victor Babes"University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Soica C; Department of Pharmaceutical Botany, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
  • Danciu C; Department of Food Science and Technology, Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine, Calea Manastur, 3-5, 400372 Cluj-Napoca, Romania.
Int J Mol Sci ; 20(23)2019 Nov 25.
Article en En | MEDLINE | ID: mdl-31775230
ABSTRACT
Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer. The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. The latest clinical evidence of the anticancer effects of CBD is also outlined. Moreover, the main aspects of the pharmacological and toxicological profiles are given.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabidiol / Cannabis / Extractos Vegetales / Fitoterapia / Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Rumanía
Texto completo
Añadir a Mi BVS
Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabidiol / Cannabis / Extractos Vegetales / Fitoterapia / Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article País de afiliación: Rumanía