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µ-opioid receptor-mediated downregulation of midline thalamic pathways to basal and central amygdala.
Goedecke, L; Bengoetxea, X; Blaesse, P; Pape, H-C; Jüngling, K.
Afiliación
  • Goedecke L; Institute of Physiology I, Westfaelische Wilhelms-Universitaet Muenster, Muenster, Germany. lena.goedecke@ukmuenster.de.
  • Bengoetxea X; Institute of Physiology I, Westfaelische Wilhelms-Universitaet Muenster, Muenster, Germany.
  • Blaesse P; Institute of Physiology I, Westfaelische Wilhelms-Universitaet Muenster, Muenster, Germany.
  • Pape HC; Institute of Physiology I, Westfaelische Wilhelms-Universitaet Muenster, Muenster, Germany.
  • Jüngling K; Institute of Physiology I, Westfaelische Wilhelms-Universitaet Muenster, Muenster, Germany.
Sci Rep ; 9(1): 17837, 2019 11 28.
Article en En | MEDLINE | ID: mdl-31780740
Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR expression in the dMT has been described, the exact cellular and synaptic mechanisms of µ-opioidergic modulation in the dMT-amygdala circuitry remain unresolved. Here, we hypothesized that MORs are important negative modulators of dMT-amygdala excitatory networks. Using retrograde tracers and targeted channelrhodopsin expression in combination with patch-clamp electrophysiology, we found that projections of dMT neurons onto both basal amygdala principal neurons (BA PN) and central amygdala (CeL) neurons are attenuated by stimulation of somatic or synaptic MORs. Importantly, dMT efferents to the amygdala drive feedforward excitation of centromedial amygdala neurons (CeM), which is dampened by MOR activation. This downregulation of excitatory activity in dMT-amygdala networks puts the µ-opioid system in a position to ameliorate aversive or defensive behavioral states associated with stress, withdrawal, physical pain or social rejection.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Receptores Opioides mu / Amígdala del Cerebelo / Neuronas Límite: Animals Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Receptores Opioides mu / Amígdala del Cerebelo / Neuronas Límite: Animals Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido