The influence of polymorphisms of xenobiotic-metabolizing and DNA repair genes in DNA damage, telomere length and global DNA methylation evaluated in open-cast coal mining workers.

de Souza, Melissa Rosa; Rohr, Paula; Kahl, Vivian Francília Silva; Kvitko, Kátia; Cappetta, Mónica; Lopes, Wilner Martinez; Simon, Daniel; da Silva, Juliana

de Souza, Melissa Rosa; Rohr, Paula; Kahl, Vivian Francília Silva; Kvitko, Kátia; Cappetta, Mónica; Lopes, Wilner Martinez; Simon, Daniel; da Silva, Juliana.

Afiliación

de Souza MR; Laboratory of Genetic Toxicology, Post-Graduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil.
Rohr P; Laboratory of Genetic Toxicology, Post-Graduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil.
Kahl VFS; Telomere Length Regulation Unit, Children's Medical Research Institute (CMRI), Sydney, Australia.
Kvitko K; Laboratory of Immunogenetics, Post-Graduate Program in Genetics and Molecular Biology (PPGBM), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Cappetta M; Laboratory of Genetic Epidemiology, Department of Genetics, Medicine School, Universidad de la República, Montevideo, Uruguay.
Lopes WM; Department of Genetic Toxicology and Chromosome Pathology, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay.
Simon D; Laboratory of Human Molecular Genetics, Post-Graduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil.
da Silva J; Laboratory of Genetic Toxicology, Post-Graduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil; Laboratory of Genetic Toxicology, La Salle University (UniLaSalle), Canoas, RS, Brazil. Electronic address: juliana.silva@ulbra.br.

Ecotoxicol Environ Saf ; 189: 109975, 2020 Feb.

Article en En | MEDLINE | ID: mdl-31787382

Asunto(s)

Minas de Carbón; Carbón Mineral/toxicidad; Daño del ADN; Metilación de ADN; Exposición Profesional; Polimorfismo Genético; Homeostasis del Telómero; Adolescente; Adulto; Anciano; Citocromo P-450 CYP1A1/genética; Reparación del ADN; Proteínas de Unión al ADN/genética; Femenino; Genotipo; Gutatión-S-Transferasa pi/genética; Glutatión Transferasa/genética; Humanos; Masculino; Persona de Mediana Edad; Proteína 1 de Reparación por Escisión del Grupo de Complementación Cruzada de las Lesiones por Rayos X/genética; Xenobióticos/metabolismo; Adulto Joven

Palabras clave

DNA damage; Genetic polymorphism; Methylation; Mineral coal; Telomere length

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Daño del ADN / Exposición Profesional / Carbón Mineral / Minas de Carbón / Metilación de ADN / Homeostasis del Telómero Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ecotoxicol Environ Saf Año: 2020 Tipo del documento: Article País de afiliación: Brasil

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