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Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Saunders, Kevin O; Wiehe, Kevin; Tian, Ming; Acharya, Priyamvada; Bradley, Todd; Alam, S Munir; Go, Eden P; Scearce, Richard; Sutherland, Laura; Henderson, Rory; Hsu, Allen L; Borgnia, Mario J; Chen, Haiyan; Lu, Xiaozhi; Wu, Nelson R; Watts, Brian; Jiang, Chuancang; Easterhoff, David; Cheng, Hwei-Ling; McGovern, Kelly; Waddicor, Peyton; Chapdelaine-Williams, Aimee; Eaton, Amanda; Zhang, Jinsong; Rountree, Wes; Verkoczy, Laurent; Tomai, Mark; Lewis, Mark G; Desaire, Heather R; Edwards, Robert J; Cain, Derek W; Bonsignori, Mattia; Montefiori, David; Alt, Frederick W; Haynes, Barton F.
Afiliación
  • Saunders KO; Human Vaccine Institute and Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA. kevin.saunders@duke.edu barton.haynes@duke.edu alt@enders.tch.harvard.edu.
  • Wiehe K; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
  • Tian M; Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.
  • Acharya P; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Bradley T; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Alam SM; Human Vaccine Institute and Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
  • Go EP; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Scearce R; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Sutherland L; Department of Chemistry, University of Kansas, Lawrence, KS 66049, USA.
  • Henderson R; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Hsu AL; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Borgnia MJ; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Chen H; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • Lu X; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
  • Wu NR; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Watts B; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Jiang C; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Easterhoff D; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Cheng HL; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • McGovern K; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Waddicor P; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Chapdelaine-Williams A; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Eaton A; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Zhang J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Rountree W; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Verkoczy L; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Tomai M; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Lewis MG; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Desaire HR; Corporate Research Materials Lab, 3M Company, St. Paul, MN 55144, USA.
  • Edwards RJ; Bioqual, Rockville, MD 20850, USA.
  • Cain DW; Department of Chemistry, University of Kansas, Lawrence, KS 66049, USA.
  • Bonsignori M; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Montefiori D; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Alt FW; Human Vaccine Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
  • Haynes BF; Human Vaccine Institute and Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Science ; 366(6470)2019 12 06.
Article en En | MEDLINE | ID: mdl-31806786

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selección Genética / Linfocitos B / Anticuerpos Anti-VIH / VIH-1 / Vacunas contra el SIDA / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Afinidad de Anticuerpos Límite: Animals / Humans Idioma: En Revista: Science Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selección Genética / Linfocitos B / Anticuerpos Anti-VIH / VIH-1 / Vacunas contra el SIDA / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Afinidad de Anticuerpos Límite: Animals / Humans Idioma: En Revista: Science Año: 2019 Tipo del documento: Article