Hormone Therapy as a Protective Factor for Age-Related Macular Degeneration.
Ophthalmic Epidemiol
; 27(2): 148-154, 2020 04.
Article
en En
| MEDLINE
| ID: mdl-31813321
ABSTRACT
Purpose:
The purpose of this study was to determine if the use of menopausal hormone therapy (HT) is related to the development of neovascular (NV) age-related macular degeneration (AMD), geographic atrophy (GA) and/or early/intermediate AMD.Methods:
A case-control study was conducted from patients prospectively recruited from July 2014 to June 2019. Cases were females with AMD recruited into a registry and controls were females with age-related cataract and no AMD. Age-related macular degeneration was categorized into NV-AMD, GA, and early/intermediate. Hormone therapy (historic and current) was self-reported by the patient and categorized as ever/never use. Adjusted odds ratios (ORs) from multinomial logistic regressions are presented for each AMD group.Results:
Female AMD case patients (n = 409) and controls (n = 132) were included in the analytic database. Almost half (45.5%) of the female AMD patients had NV-AMD, 14.9% had GA, and 39.6% had early/intermediate AMD. Among all study participants, 285 (52.7%) reported historic and/or current use of HT. Controls were significantly more likely to have any HT use (71.2%), compared to 43.0% (p ≤ 0.001) of NV-AMD patients, 47.5% (p = .002) of GA patients, and 50.6% (p ≤ 0.001) of early/intermediate AMD patients. Adjusted for potential confounders of age and Caucasian race, cases were significantly more likely to have lower HT use compared to controls NV-AMD, OR = 0.31 (95%CI 0.18-0.54), GA, OR = 0.40 (95%CI 0.20-0.80), and early/intermediate AMD, OR = 0.36 (95%CI 0.22-0.61).Conclusion:
Our case-control study found that the use of HT was associated with a lower odds of all AMD stages studied NV-AMD, GA and early/intermediate.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Terapia de Reemplazo de Estrógeno
/
Neovascularización Retiniana
/
Atrofia Geográfica
/
Degeneración Macular
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Ophthalmic Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
/
OFTALMOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos