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Associating Psychotic Symptoms with Altered Brain Anatomy in Psychotic Disorders Using Multidimensional Item Response Theory Models.
Stan, Ana D; Tamminga, Carol A; Han, Kihwan; Kim, Jong Bae; Padmanabhan, Jaya; Tandon, Neeraj; Hudgens-Haney, Matthew E; Keshavan, Matcheri S; Clementz, Brett A; Pearlson, Godfrey D; Sweeney, John A; Gibbons, Robert D.
Afiliación
  • Stan AD; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Tamminga CA; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Han K; Advance MRI, LLC, Frisco, TX 75034, USA.
  • Kim JB; Departments of Medicine and Public Health Sciences, University of Chicago, Chicago, IL 60637, USA.
  • Padmanabhan J; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
  • Tandon N; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
  • Hudgens-Haney ME; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Keshavan MS; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
  • Clementz BA; Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens, GA 30602, USA.
  • Pearlson GD; Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT; Institute of Living, Hartford Hospital, Hartford, CT 06106, USA.
  • Sweeney JA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45221, USA.
  • Gibbons RD; Departments of Medicine and Public Health Sciences, University of Chicago, Chicago, IL 60637, USA.
Cereb Cortex ; 30(5): 2939-2947, 2020 05 14.
Article en En | MEDLINE | ID: mdl-31813988
Reduced cortical thickness has been demonstrated in psychotic disorders, but its relationship to clinical symptoms has not been established. We aimed to identify the regions throughout neocortex where clinical psychosis manifestations correlate with cortical thickness. Rather than perform a traditional correlation analysis using total scores on psychiatric rating scales, we applied multidimensional item response theory to identify a profile of psychotic symptoms that was related to a region where cortical thickness was reduced. This analysis was performed using a large population of probands with psychotic disorders (N = 865), their family members (N = 678) and healthy volunteers (N = 347), from the 5-site Bipolar-Schizophrenia Network for Intermediate Phenotypes. Regional cortical thickness from structural magnetic resonance scans was measured using FreeSurfer; individual symptoms were rated using the Positive and Negative Syndrome Scale, Montgomery-Asberg Depression Rating Scale, and Young Mania Rating Scale. A cluster of cortical regions whose thickness was inversely related to severity of psychosis symptoms was identified. The regions turned out to be located contiguously in a large region of heteromodal association cortex including temporal, parietal and frontal lobe regions, suggesting a cluster of contiguous neocortical regions important to psychosis expression. When we tested the relationship between reduced cortical surface area and high psychotic symptoms we found no linked regions describing a related cortical set.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicometría / Trastornos Psicóticos / Imagen por Resonancia Magnética / Neocórtex / Análisis de Escalamiento Multidimensional Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicometría / Trastornos Psicóticos / Imagen por Resonancia Magnética / Neocórtex / Análisis de Escalamiento Multidimensional Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos