Multimodal assessment of sleep in men and women during treatment for opioid use disorder.
Drug Alcohol Depend
; 207: 107698, 2020 02 01.
Article
en En
| MEDLINE
| ID: mdl-31816489
ABSTRACT
BACKGROUND:
Sleep disturbance is common in patients with opioid use disorder (OUD) receiving medication for addiction treatment. Differences between patients on the two primary agonist medications-methadone and buprenorphine-are not well understood.METHODS:
In patients receiving either methadone or buprenorphine treatment for OUD, we examined sleep continuity and architecture using ambulatory monitoring to gather both an objective measure (daily sleep EEG; Mâ¯=â¯5.76 days, SDâ¯=â¯1.46) and a subjective measure (daily sleep diary; Mâ¯=â¯54.10 days, SDâ¯=â¯25.10) of sleep.RESULTS:
Patients treated with buprenorphine versus methadone did not differ on any measure of sleep continuity or architecture. Women had longer EEG-derived total sleep time than men (d = -0.68, 95 % CI -1.32 to -0.09), along with lower %N2 (dâ¯=â¯0.94, 95 % CI 0.34-1.64) and greater %N3 (d = -0.94, 95 % CI -1.61 to -0.32). Self-reported sleep differed from EEG-derived estimates wake after sleep onset was greater by EEG than by diary (dâ¯=â¯2.58, 95 % CI 1.74-3.63), and total sleep time and sleep efficiency were lower by EEG than by diary (d for sleep timeâ¯=â¯2.93, 95 % CI 2.06-4.14; d for efficiencyâ¯=â¯1.69, 95 % CI 0.98-2.49).CONCLUSIONS:
Patients treated with buprenorphine or methadone did not substantively differ in ambulatory measures of sleep. With both medications, there was a discrepancy between objective and subjective sleep measures. Further confirmatory evidence would inform the development of sleep-related recommendations for OUD patients undergoing agonist treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos del Sueño-Vigilia
/
Buprenorfina
/
Tratamiento de Sustitución de Opiáceos
/
Analgésicos Opioides
/
Metadona
/
Trastornos Relacionados con Opioides
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Drug Alcohol Depend
Año:
2020
Tipo del documento:
Article