Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca<sup>2+</sup> Overload.

Lee, A Reum; Seo, Min Ji; Kim, Jin; Lee, Dong Min; Kim, In Young; Yoon, Mi Jin; Hoon, Hur; Choi, Kyeong Sook

Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca²⁺ Overload.

Lee, A Reum; Seo, Min Ji; Kim, Jin; Lee, Dong Min; Kim, In Young; Yoon, Mi Jin; Hoon, Hur; Choi, Kyeong Sook.

Afiliación

Lee AR; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Korea.
Seo MJ; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Korea.
Kim J; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Korea.
Lee DM; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Korea.
Kim IY; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Korea.
Yoon MJ; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Korea.
Hoon H; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Korea.
Choi KS; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Korea.

Int J Mol Sci ; 20(24)2019 Dec 04.

Article en En | MEDLINE | ID: mdl-31817163

Asunto(s)

Bortezomib/farmacología; Calcio/metabolismo; Dihidropiridinas/farmacología; Estrés del Retículo Endoplásmico/efectos de los fármacos; Mitocondrias/efectos de los fármacos; Inhibidores de Proteasoma/farmacología; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Sinergismo Farmacológico; Humanos; Iones/química; Mitocondrias/metabolismo; Vacuolas/efectos de los fármacos; Vacuolas/metabolismo

Palabras clave

ER stress; bortezomib; lercanidipine; mitochondrial Ca2+ overload; paraptosis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dihidropiridinas / Calcio / Estrés del Retículo Endoplásmico / Inhibidores de Proteasoma / Bortezomib / Mitocondrias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2019 Tipo del documento: Article Pais de publicación: Suiza

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