Are the Hydantoin-1,3,5-triazine 5-HT<sub>6</sub>R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.

Lubelska, Annamaria; Latacz, Gniewomir; Jastrzebska-Wiesek, Magdalena; Kotanska, Magdalena; Kurczab, Rafal; Partyka, Anna; Marc, Malgorzata Anna; Wilczynska, Daria; Doroz-Plonka, Agata; Lazewska, Dorota; Wesolowska, Anna; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga

Are the Hydantoin-1,3,5-triazine 5-HT₆R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.

Lubelska, Annamaria; Latacz, Gniewomir; Jastrzebska-Wiesek, Magdalena; Kotanska, Magdalena; Kurczab, Rafal; Partyka, Anna; Marc, Malgorzata Anna; Wilczynska, Daria; Doroz-Plonka, Agata; Lazewska, Dorota; Wesolowska, Anna; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga.

Afiliación

Lubelska A; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Latacz G; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Jastrzebska-Wiesek M; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Kotanska M; Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Kurczab R; Department of Medicinal Chemistry Maj Institute of Pharmacology, Polish Academy of Science, Smetna 12, PL 31-343 Cracow, Poland.
Partyka A; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Marc MA; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Wilczynska D; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Doroz-Plonka A; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Lazewska D; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Wesolowska A; Department of Clinical Pharmacy, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Kiec-Kononowicz K; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.
Handzlik J; Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Cracow, Poland.

Molecules ; 24(24)2019 Dec 06.

Article en En | MEDLINE | ID: mdl-31817628

Asunto(s)

Antagonistas de la Serotonina/química; Triazinas/química; Animales; Fármacos Antiobesidad; Células CACO-2; Humanos; Hidantoínas/química; Masculino; Estructura Molecular; Unión Proteica; Ratas Wistar; Receptores de Serotonina; Relación Estructura-Actividad

Palabras clave

1,3,5-triazine; 5-HT6R antagonist; ADME-Tox parameters; hydantoin; obesity; procognitive effect

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antagonistas de la Serotonina / Triazinas Límite: Animals / Humans / Male Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza

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