The Influence of Dietary Fatty Acids on Immune Responses.
Nutrients
; 11(12)2019 Dec 06.
Article
en En
| MEDLINE
| ID: mdl-31817726
ABSTRACT
Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural components of cells. They also play important roles in the modulation of immune responses in health and disease. Saturated and unsaturated FAs influence the effector and regulatory functions of innate and adaptive immune cells by changing membrane composition and fluidity and by acting through specific receptors. Impaired balance of saturated/unsaturated FAs, as well as n-6/n-3 polyunsaturated FAs has significant consequences on immune system homeostasis, contributing to the development of many allergic, autoimmune, and metabolic diseases. In this paper, we discuss up-to-date knowledge and the clinical relevance of the influence of dietary FAs on the biology, homeostasis, and functions of epithelial cells, macrophages, dendritic cells, neutrophils, innate lymphoid cells, T cells and B cells. Additionally, we review the effects of dietary FAs on the pathogenesis of many diseases, including asthma, allergic rhinitis, food allergy, atopic dermatitis, rheumatoid arthritis, multiple sclerosis as well as type 1 and 2 diabetes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Grasas Insaturadas en la Dieta
/
Grasas de la Dieta
/
Ácidos Grasos
/
Inmunidad Adaptativa
/
Inmunidad Innata
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Nutrients
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suiza