[New possibilities in antibacterial treatment of intra-abdominal infections caused by multiresistant microflora]. / Novye vozmozhnosti antibakterial'noi terapii intraabdominal'nykh infektsii, vyzvannykh polirezistentnoi mikrobnoi floroi.
Khirurgiia (Mosk)
; (12): 74-83, 2019.
Article
en Ru
| MEDLINE
| ID: mdl-31825346
ABSTRACT
AIM:
To determine the place of new drugs with activity against multidrug resistant strains of microorganisms in the treatment of complicated intraabdominal infections. MATERIAL ANDMETHODS:
The incidence and distribution of pathogens isolated from intra-abdominal specimens in patients with intra-abdominal infections are analyzed.RESULTS:
The current situation on the growth of resistant strains among pathogens causing intra-abdominal infections is rewied. New combined drugs for the treatment of multidrug resistant infections - ceftolozane/tazobactam and ceftazidim/avibactam plus metronidazole, has been suggested. Their potential role in empiric and targeted antibacterial treatment of complicated intraabdominal infections is defined.CONCLUSION:
Taking into consideration local monitoring data and risk factors of multi resistant strains Ceftolozane/tazobactam in combination with metronidazole can be used in empiric regime of treatment. Due to the high activity on carbapenem resistant strains of Klebsiella pneumonia and the lack of alternatives, it is advisable to use Ceftazidim/avibactam for the targeted therapy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Farmacorresistencia Bacteriana Múltiple
/
Infecciones Intraabdominales
/
Antibacterianos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
Ru
Revista:
Khirurgiia (Mosk)
Año:
2019
Tipo del documento:
Article
País de afiliación:
Rusia