Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors.
Chem Commun (Camb)
; 56(3): 466-469, 2020 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-31828267
ABSTRACT
We herein report a new approach for RNA interference, so-called "build-up RNAi" approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in aspects of immunogenicity and cellular uptake.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Precursores del ARN
/
ARN Interferente Pequeño
/
Interferencia de ARN
/
ARN Circular
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM