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Impact of cadmium toxicity on cartilage loss in a 3D in vitro model.
Yessica Eduviges, Zamudio-Cuevas; Martínez-Nava, Gabriela; Reyes-Hinojosa, Daniel; Mendoza-Soto, Luzia; Fernández-Torres, Javier; López-Reyes, Alberto; Olivos-Meza, Anell; Armienta-Hernández, María Aurora; Ruíz-Huerta, Esther Aurora; de Jesús González-Guadarrama, María; Sandoval, Bertha Vargas; Landa-Solís, Carlos; Sánchez-Sánchez, Roberto; Suarez-Ahedo, Carlos; Lozada-Pérez, Carlos Alberto; Gutiérrez-Ruiz, María Concepción; Clavijo-Cornejo, Denise; Pineda, Carlos; Jacobo-Albavera, Leonor; Domínguez-Pérez, Mayra; Martínez-Flores, Karina.
Afiliación
  • Yessica Eduviges ZC; Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Martínez-Nava G; Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Reyes-Hinojosa D; Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Mendoza-Soto L; Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Fernández-Torres J; Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • López-Reyes A; Gerosciences, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Olivos-Meza A; Orthopedic Sports Medicine and Arthroscopy Service, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Armienta-Hernández MA; Departament of Natural Resources, Institute of Geophysics, UNAM. Circuito de la investigación Científica s/n, Ciudad Universitaria, Cd. Universitaria, C.P. 04150. Mexico City, Mexico.
  • Ruíz-Huerta EA; Departament of Natural Resources, Institute of Geophysics, UNAM. Circuito de la investigación Científica s/n, Ciudad Universitaria, Cd. Universitaria, C.P. 04150. Mexico City, Mexico.
  • de Jesús González-Guadarrama M; Departament of Natural Resources, Institute of Geophysics, UNAM. Circuito de la investigación Científica s/n, Ciudad Universitaria, Cd. Universitaria, C.P. 04150. Mexico City, Mexico.
  • Sandoval BV; Microscopy Laboratory, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Landa-Solís C; Tissue Engineering and Cell Therapy and Regenerative Medicine Unit, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Sánchez-Sánchez R; Tissue Engineering and Cell Therapy and Regenerative Medicine Unit, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Suarez-Ahedo C; Departament of Adult Joint Reconstruction, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Lozada-Pérez CA; Rheumatology Service, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico.
  • Gutiérrez-Ruiz MC; Department of Health Sciences, Autonomous Metropolitan University, Laboratory of Experimental Medicine, Unit of Translational Medicine, Institute of Biomedical Research, UNAM, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
  • Clavijo-Cornejo D; Division of Musculoskeletal and Rheumatic Disorders. National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico City, Mexico.
  • Pineda C; Division of Musculoskeletal and Rheumatic Disorders. National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico City, Mexico.
  • Jacobo-Albavera L; Genomics of Cardiovascular Diseases Laboratory, National Institute of Genomic Medicine, Periférico Sur 4809, Col. Arenal Tepepan, C.P. 14610, Mexico.
  • Domínguez-Pérez M; Genomics of Cardiovascular Diseases Laboratory, National Institute of Genomic Medicine, Periférico Sur 4809, Col. Arenal Tepepan, C.P. 14610, Mexico.
  • Martínez-Flores K; Synovial Fluid, National Institute of Rehabilitation, Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, C.P. 14389, Mexico. Electronic address: karinabiologist@hotmail.com.
Environ Toxicol Pharmacol ; 74: 103307, 2020 Feb.
Article en En | MEDLINE | ID: mdl-31830724
ABSTRACT
Osteoarthritis (OA) is the gradual loss of articular cartilage and decrease in subchondral space. One of the risk factors Exposure to cadmium (Cd) through tobacco smoke has been identified as a major OA risk factor. There are no reports addressing the role of Cd in OA progression at the molecular level. Our findings revealed that Cd can promote the activation of metalloproteinases (MMP1, MMP3, MMP9 y MMP13), affecting the expression of COL2A1 and ACAN, and decreasing the presence of glycosaminoglycans and proteoglycans through an inflammatory response related to IL-1ß y a IL-6, as well as oxidative by producing ROS like O2-• and H2O2. In conclusion, our findings suggest a cytotoxic role of Cd in the articular cartilage, which could affect OA development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Cadmio / Sustancias Peligrosas / Cartílago Articular Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Environ Toxicol Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: México
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Cadmio / Sustancias Peligrosas / Cartílago Articular Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Environ Toxicol Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: México